Three women have been seriously injured after a road traffic collision on the A34 between Kidsgrove and Congleton.
It involved a lorry and a car at the junction of Dodds Lane in Astbury just before 2.30am.
Three women were taken to the Royal Stoke University Hospital.
A road closure is in place between West Road in Congleton and the A34 Scholar Green.
Diversions are in place but motorists are advised to avoid the area.
If anyone has any information or dash cam footage they are urged to contact Cheshire Police on 101 quoting IML 738643.