321 people had to wait more than 12 hours to be admitted from A&E's at the Royal Stoke and County Hospital in Stafford last month.
The is the second highest figure in the country.
The latest waiting times for Emergency departments at hospital's across the NHS in England show their worst ever performance.
Nationally just under 80% of patients were seen within four hours - the target 95%
At Crewe's Leighton Hospital, just 57.6% of those who attended were seen within that time.
6,043 patients at the Royal Stoke had to wait for more than four hours.
The figures come just days after the trust that runs the Royal Stoke and County Hospital sent out a plea for people not to go to A&E unless for life threatening emergencies, ahead of what is traditionally their busiest weekend and week.
Bosses said outbreaks of flu and winter vomiting bug (Norovirus) have also not helped ease pressures.
Today, John Oxtoby, Medical Director at University Hospital of North Midlands NHS Trust said: “Ideally we would not want any of our patients to wait in our A&E, however, this is sometimes unavoidable at exceptionally busy times while we see and treat the most seriously ill.
"We know long waits can be distressing for patients and their families and apologise to those who have experienced this.
“UHNM is one of almost a hundred NHS trusts across the country that are not meeting A&E performance targets. Winter pressures and pressures generally is a nationwide issue due to increasing elderly population and the complexity of the illnesses they have.
"Credit must be given to our incredible staff who work tirelessly to keep our patients safe while treating an astonishing number of patients.
“We are working to prevent admissions, improve discharges and increase access to NHS services across Staffordshire.”
Chris Oliver, Chief Operating Officer at Mid Cheshire Hospitals NHS Foundation Trust, said: “A&Es across the country have seen an increase in attendances over the last year and Leighton Hospital is no exception – we have witnessed around 500 more people a month attend A&E, which is more than double the national average. For our community, this is partly due to a growing and ageing population with more complicated health needs.
“To help keep up with demand, we have opened additional beds, invested heavily in our Emergency Department’s workforce and have recently expanded Leighton Hospital’s A&E.
“Despite current demand, staff across the Trust continue to work hard to ensure patient safety and that services run as smoothly as possible and we would like to thank them for their dedication. The demand has meant, however, that some patients have had to wait longer than usual to be treated and we would like to apologise to those affected.
“The public can also help NHS staff by choosing the most appropriate service for them. This includes calling 111 or visiting 111.nhs.uk if you need medical help fast but it’s not an emergency.”