Stoke City were beaten 3-1 at Brentford in Nathan Jones' first game in charge.
The Potters were two down inside the opening 17 minutes through a Ryan Shawcross and a strike from Said Benrahma.
A stunning strike from Benik Afobe reduced the arrears midway through the half.
But a second half goal from Rico Henry nine minutes after the restart sealed victory for the Bees.
Stoke are now 15th in the table eight points off the play-off places.
The Potters are back in action on Tuesday night when they entertain Shrewsbury in an FA Cup replay.